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SRG1 RNA
SRG1 RNA ((''SER3'' ) regulatory gene 1) is a non-coding RNA which represses the expression of ''SER3'' (YER081W).〔(【引用サイトリンク】title=Entrez Gene SRG1 )〕〔(【引用サイトリンク】title=Yeast Genome SRG1 )〕 ''SER3'' is a gene which codes for a phosphoglycerate dehydrogenase involved in the biosynthesis of serine. SRG1 represses ''SER3'' expression via transcription interference, and in that respect is the first intergenic transcript of its kind.〔 SRG1 was identified when chromatin immunoprecipitation (ChIP) assays showed that in ''Saccharomyces cerevisiae'', even when ''SER3'' was being repressed, TATA-binding protein and RNA Polymerase II were still bound to the ''SER3'' DNA in such a way that should have caused active transcription.〔 Further analysis found a second TATA box 558 bp upstream of ''SER3''. A bioinformatic scan identified this same TATA box element in related ''Saccharomyces''. SRG1 has been found to be cis-acting, it had no repressive effect when in trans.〔 SRG1 RNA is unrelated to Senescence Related Gene 1 (SRG1), a protein-coding gene found in ''Arabidopsis thaliana'',〔(【引用サイトリンク】title=Uniprot Knowledgebase - Protein SRG1 )〕 and is also distinct from Stress Response Gene 1 (SRG1) found in ''Medicago sativa''.〔(【引用サイトリンク】title=GenBank Accs:U42752.1 )〕 ==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「SRG1 RNA」の詳細全文を読む
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